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pairing with metformin targets complementary nutrient-sensing pathways
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A holistic approach to obesity management incorporating behavioural support alongside pharmacotherapy is generally recommended in line with NICE guidance on weight management interventions
Consequently, new theories around the modes of action for SGLT2 inhibitors and GLP-1 RAs are being hypothesised [112, 117,118,119], although as yet it remains unclear which mechanism(s) are responsible, or whether there is any mechanistic overlap between cardiorenal benefits with SGLT2 inhibitors and GLP-1 RAs
The occipital artery and the pterygopalatine artery (PPA) were permanently ligated
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